Conference Abstracts

Oral / Platform Presentations

  
2010 AAN 62nd Annual Meeting:
Antibodies (gMS® Dx Test) Differentiate Newly Diagnosed Relapsing Remitting Multiple Sclerosis Patients from Other Inflammatory Demyelinating Disease Patients within One Year from Diagnosis.

2006 AUTOIMMUNITY 5th International Congress:
Prognosis in Multiple Sclerosis.
C Sindic. Abstracts of 5th international Congress on Autoimmunity, Autoimmunity Reviews.
2006; ISSN 1568-9972:p 203.

 

2006 ACTRMS 11th Annual Meeting:
Validation of anti-GAGA4 IgM antibodies for predicting the development of relapsing remitting MS after the first neurological event.
MS Freedman, J Laks, N Dotan, RT Altstock, A Dukler and C Sindic
Mult Scler  2007; 13: 278-230.

 

2005 ECTRIMS/ACTRIMS Joint Meeting:
Anti-Glc(alpha 1,4)Glc(alpha) IgM Antibodies for Predict the Development of Relapsing Remitting Multiple Sclerosis after the First Neurological Event.
MS Freedman, N Dotan, M Schwarz, O Weishaus, A Dukler, A Miller, and C Sindic
Mult Scler  2005; 11-S1: 180 P678.

 

2004 International Society of Neuroimmunology 7th International Congress:
The use of GlycoChip® microarray technology for identification of anti-Glc(alpha 1,4)Glc(alpha)-serum antibodies as specific biomarker for multiple sclerosis.
M. Schwarz, L Spector, M Gortler, L Glass-Marmor, A Karni, N Dotan and A Miller.
Journal of Neuroimmunol 2004; 154: P325. 

Poster Presentations

 

 

2009 ACTRIMS:

2009 ECTRIMS:
Anti-alpha-glucose based glycan IgM antibodies in patients with a clinically isolated syndrome:
analyses from the BEtaferon® in Newly Emerging multiple sclerosis For Initial Treatment (BENEFIT) study
M Freedman, G Edan, HP Hartung, L Kappos, D Miller, X Montalban, CH Polman, N Dotan, V Lanius,
C Metzig, S Schwenke, C Pohl, R Sandbrink for the BENEFIT Study Group
Mult Scler 2009; 15: S71.

2008 ACTRIMS/ECTRIMS/LACTRIMS Joint Meeting:
Performance of an anti-GAGA4 IgM assay in distinguishing multiple sclerosis patients from control groups in a US cohort: a cross sectional retrospective study
TD Jaskowski, D Husebye, HS Seraj, J Yarden, L Spector, E Fire, N Dotan, HR Hill, JW Rose
Mult Scler 2008; 14: S282.

 

A successful validation of the ability of anti-GAGA4 IgM antibody assay to differentiate multiple sclerosis patients from other neurological diseases patients in a German cohort: a cross-sectional retrospective analysis.
J Brettschneider, S Abdul, E Fire, J Yarden, L Spector, N Dotan, H Tumani
Mult Scler 2008; 14: S290.

 

2006 ECTRIMS 22nd Conference:
A panel of anti-glycan IgM antibodies for predicting the development of relapsing-remitting multiple sclerosis after the first neurological event.
MS Freedman, A Miller, M Schwarz, O Weishaus, RT Altstock, A Dukler, N Dotan, C Sindic
Mult Scler 2006; 12: S167.

 

2004 ECTRIMS 20th Conference:
Anti-Glc(alpha 1,4)Glc(alpha)-specific serum antibodies in patients with multiple sclerosis for use in disease management
M. Schwarz, L Spector, M Gortler, L Glass-Marmor, A Karni, N Dotan and A Miller.
Mult Scler 2004; 10:S97-283.

 

 

 

Anti-glycan antibodies as biomarkers for diagnosis and prognosis 
N Dotan, RT Altstock, M Schwarz, A Dukler
Lupus 2006;15:442-450

Role of biomarkers in the diagnosis of inflammatory bowel disease
S Vermeire, G Van Assche and P Rutgeerts
Expert Opin Med Diagn 2007 1:481-488
 
The role of microbes in Crohn's disease.
PB Eckburg, DA Relman.
Clin Infect Dis;44256-62... 2007 

CONFERENCES 

ORAL / PLATFORM PRESENTATIONS

2008 Digestive Disease Week

The novel anti-glycan antibodies Anti-L and Anti-C in conjunction with ALCA, ACCA, gASCA and AMCA predict early development of fistulae, stenoses and surgery in patients with Crohn's disease: a prospective analysis
F Rieder, A Wolf, S Schleder, A Dirmeier, U Strauch, F Obermeier, F Spector, E Fire, J Yarden, G Rogler, N Dotan, F Klebl
Gastroenterology 2008; 134:S1, A-53

Specific levels and combinations of the anti-glycan antibodies Anti-L, Anti-C, ALCA, ACCA, gASCA and AMCA contribute to diagnosis and differential diagnosis of patients with Crohn's disease and are associated with complicated disease and surgery
F Rieder, A Wolf, S Schleder, A Dirmeier, U Strauch, F Obermeier, F Spector, E Fire, J Yarden, G Rogler, N Dotan, F Klebl
Gastroenterology 2008; 134:S1, A-53

Two novel polysaccharide antibodies (anti-laminarin and anti-chitin) predict an aggressive Crohn's disease phenotype and improve differentiation between Crohn's disease and ulcerative colitis
CH Seow, JM Stempak, W Xu, H Lan, AM Griffiths, GR Greenberg, AH Steinhart, N Dotan, MS Silverberg
Gastroenterology 2008; 134:S1, A 53

2008 Canadian Digestive Disease Week

The utility of two novel polysaccharide antibodies (Anti-laminarin and anti-chitin) in diagnosing Crohn's disease and their association with aggressive disease
CH Seow, JM Stempak, W Xu, H Lan, AM Griffiths, GR Greenberg, AH Steinhart, N Dotan, and MS Silverberg
Can J Gastroenterol 2008; 22:SA, 78A

Serum ASCA and Smoking Status are Associated with a Crohn's Disease-like Phenotype after Pelvic Pouch Surgery for Ulcerative Colitis
D Verbeeten, R Milgrom, W Xu, J Stempak, A Hillary Steinhart, G Greenberg1, R McLeod1, Z Cohen1, MS Silverberg
Can J Gastroenterol 2009; 23:SA, 69A

2006 Digestive Disease Week

A panel of serological antibodies (gASCA, Omp, ACCA, ALCA and AMCA) predicts complicated disease course and surgery in Crohn's disease.
M Ferrante, M Pierik, L Henckaerts, N Dotan, GL Norman, RT Altstock, I Dotan, Z Shums, B Schooler, K Claes, N Van Schuerbeek, G Van Assche, P Rutgeerts and S Vermeire
Gastroenterology 2006,130:S2, A 25 

POSTER PRESENTATIONS

2008 Digestive Disease Week

Ulcerative colitis patients after pouch surgery have Crohn's disease associated serologies which are associated with pouch inflammation
I Dotan, H Tulchinsky, H Zinger, N Horowitz, I Goldiner, E Brazowski, Z Halpern
Gastroenterology 2008; 134:S1,A198

2008 16th United European Gastroenterology Week

Pancreatic autoantibodies are associated with reactivity to microbial antibodies, penetrating disease behavior, perianal disease and extraintestinal manifestations, but not with NOD2/CARD15 or TLR4 genotype in a HUNGARIAN IBD cohort
P L Lakatos, I. Altorjay, T Szamosi, K Palatka, Z Vitalis, J Tumpek, S Sipka, M Udvardy, T Dinya, L Lakatos, A Kovacs, T Molnar, Z Tulassay, P Miheller, Z Barta, . Stocker, J Papp, Hungarian IBD Study Group, M. Papp
UEGW 2008 - Abstract Database, P0168
http://www.uegf.org/publications/abstracts2008/abstract_detail.php?aId=P0168&navId=218

Fungal colonization of gastrointestinal tract, anti-saccharomyces cervisiae antibodies anti-mannan candida Spp. antibodies in inflammatory bowel disease in comparison with irritable bowel syndrome
J. Semianow-Wejchert, U. Nawrot, D. Ksiadzyna, K. Wlodarczyk, A. Annabhani
UEGW 2008 - Abstract Database, P0683
http://www.uegf.org/publications/abstracts2008/abstract_detail.php?aId=P0683&navId=218

Novel biomarkers of Crohn's disease consisting in antibodies against synthetic disaccharides fragments of glucan and chitin (ALCA and ACCA), as well as ASCA, are generated during a Candida Albicans infection
B Sendid, C Savaux, N Dotan, P Vandewalle, L Richard, A Standaert, B Guery, A Dukler, J Colombel, D Poulain
UEGW 2008 - Abstract Database, P0136
http://www.uegf.org/publications/abstracts2008/abstract_detail.php?aId=P0136&navId=218

2007 15th United European Gastroenterology Week

Anti-glycan antibodies markers are useful for differentiation between Crohn's disease and ulcerative colitis in children
N Dotan, RT Altstock, E Fire, M Gortler, L Spector, JM Stempak, AM Griffiths, MS Silverberg
Gut 2007;56:S3, A137

Increasing prevalence of anti-glycan antibodies markers associated with aggressive CD behavior in a Canadian cohort
N Dotan, A Elkadri, AH Steinhart, GR Greenberg, RS McLeod, Z Cohen, E Fire, RT Altstock, L Spector, M Gortler, JM Stempak, MS Silverberg
Gut 2007; 56:S3, A137

Anti-glycan antibodies in celiac disease before and after gluten-free diet
M Papp, I Foldi, J Tumpek, C Varvolgyi, Z Bartha, S Sipka, N Dotan, IR Korponay-Szab?, E Nemes, V G?bor, I Altorjay, PL Lakatos
Gut 2007; 56:S3, A109

Comparing conventional and gASCA tests for the diagnosis and determination of clinical phenotype in Crohn's disease
P L Lakatos, I Altorjay, N Dotan, J Tumpek, S Sipka, G Lakos, M Udvardy, K Palatka, L Lakatos, A Kovacs, T Molnar, Z Tulassay, P Miheller, G L Norman, Z Shums, T Szamosi, J Papp, the Hungarian IBD Study Group*, M Papp
Gut 2007; 56:S3, A119

2007 Digestive Disease Week

Serum levels of AMCA, ALCA, ACCA and gASCA in conjunction with pANCA may contribute to the diagnosis and differentiation of inflammatory bowel disease
F Rieder, A Wolf, S Schleder, A Dirmeier, M Gruengard, U Strauch, F Obermeier, B Salzberger, Rogler G, Dotan N, Klebl F
Gastroenterology 2007; 132: No.4, S2: A-652

2006 Digestive Disease Week

Mutations in innate immune receptors modulate the serologic response to microbial antigens in patients with inflammatory bowel disease
L Henckaerts, M Pierik, K Claes, M Ferrante, N Van Schuerbeek, N Dotan, G Norman, RT Altstock, I Dotan, B Schooler, Z Shums, P Rutgeerts, S Vermeire
Gastroenterology 2006,130:S2, T1974: A-585

A panel of Anti-Glycan Antibodies (gASCA, ALCA, ACCA and AMCA) in the diagnosis and differential diagnosis of IBD
M Ferrante, M Pierik, L Henckaerts, N Dotan, RT Altstock, I Dotan, M Joossens, S Joossens, K Katsanos, K Claes, N Van Schuerbeek, G Van Assche, P Rutgeerts and S Vermeire. Gastroenterology 2006;130:S2, S1315: A-200

Anti-laminaribioside and anti-chitobioside antibodies as predictors of Crohn's disease
E Israeli, I Grotto, M Blank, L Anafi, E Goldin and Y Shoenfeld
Gastroenterology 2006;130: S2:S1369: A-212

2005 Digestive Disease Week

Improved IBD diagnosis via ELISA detecting novel antibodies: Anti-chitobioside carbohydrate antibodies (ACCA), anti-laminaribioside carbohydrate antibodies (ALCA) and anti-mannobioside carbohydrate antibodies (AMCA)RT Altstock, 
A Shtevi, A Karban, N Dotan, Z Halpern, I Dotan
Gastroenterology 2005;128:A-303.

Mixed IBD Families: A distinct entity within IBD
M Joossens, M Pierik, L Henckaerts, S Joossens, K. Claes, P Rutgeerts, S Vermeire
Gastroenterology 2006; 130:S2

2004 Digestive Disease Week

Anti-Laminarobioside Carbohydrate Antibodies (ALCA) and Anti-Chitobiose Carbohydrate Antibodies (ACCA) are Novel Serologic Markers Specific for Crohn's Disease
I Dotan, S Fishman, R Kariv, Y Dgani, M Schwartz, A Gargir, L Spector, R Altstock, Z Halpern, N Dotan
Gastroenterology 2004;125 S2:A203
Z Guo , Q Wang, Curr Opin Chem Biol. 2009
GR D'Haens, R Fedorak, M Lémann, BG Feagan, MA Kamm, J Cosnes, PJ Rutgeerts, P Marteau, S Travis, J Schölmerich, S Hanauer, WJ Sandborn; IOIBD Membership.
Inflamm Bowel Dis. 2009 ;10:1599-604

 

JBC Online (April 2004)

 

Advanced Microarray strategies for Biopharmaceuticals 2004
Oral Presentation

 

Glycobiology (October 2003)

 

Glycobiology (July 2003)

 

Trends in Glycoscience and Glycotechnology (May 2002)

 

INTERLEC 20; 2002
Oral Presentation

Nature Biotechnology (October 2001)